The British tabloid The Daily Mail reports that inside the hundreds of pages of the memoir are claims by Knox that she was sexually harassed by prison guard Raffaele Argiro, saying he would summon her for "chit chats" alone in his office at night.
In the book, Knox reportedly expands on letters she wrote to friends saying the guard was fixated on the topic of sex, asking her about partners and if she would have sex with him. Argiro has denied the allegations.
Knox also reportedly writes about a female inmate who wanted to start a lesbian affair, about how she was falsely told by officials that she was HIV positive, and about her reaction to the hate campaign that followed her release, when prosecutor's in Italy called her a "she devil" and a "witch."
HarperCollins is publishing Knox's book, a deal reportedly worth $4 million.
Knox will talk with ABC News anchor Diane Sawyer in a prime-time special to be broadcast April 30 to promote her book.
In the meantime, Knox is back taking classes at the University of Washington, where she's focusing on creative writing.